Janssen signs JAK pact with Theravance | February 12, 2018 Issue - Vol. 96 Issue 7 | Chemical & Engineering News
Volume 96 Issue 7 | p. 12 | Concentrates
Issue Date: February 12, 2018

Janssen signs JAK pact with Theravance

By Ryan Cross
Department: Business
Keywords: Drug development, JAK, JAK kinase, JAK inhibitor, Janssen, Theravance, Celgene, Impact Biosciences

Interest in inhibiting the Janus kinase (JAK) family of enzymes to reduce cytokine-induced inflammation continues to grow. Janssen Biotech, a division of Johnson & Johnson, has signed a pact to codevelop and commercialize an anti-JAK compound from Theravance Biopharma called TD-1473. This year, Theravance will test TD-1473, designed to work primarily in the gastrointestinal tract, in a Phase IIb/III study in ulcerative colitis and a Phase II study in Crohn’s disease. Janssen will pay Theravance $100 million up front and up to $900 million more in milestone payments. Just last month, Celgene acquired Impact Biosciences for its JAK2 inhibitor fedratinib.

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