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Aiming to advance its radioligand cancer therapy program, Novartis will acquire Endocyte, an Indiana-based firm that conjugates cancer-targeting small molecules to cell-killing radioisotopes. The acquisition, valued at $2.1 billion, will net Novartis a potential first-in-class radioligand therapy for metastatic castration-resistant prostate cancer (mCRPC) in Phase III development. Lu-PSMA-617 targets the prostate-specific membrane antigen present in most mCRPC patients. Novartis will also pick up radioligand programs in early-stage development.
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