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Regulus Therapeutics, a biotech firm developing oligonucleotide drugs that target microRNAs, will cut 60% of its workforce, or about 35 jobs. The decision follows the observation of acute mouse toxicity in a Phase I study of RGLS4326, a treatment for autosomal dominant polycystic kidney disease. The firm also halted recruitment for a study of a microRNA drug it is developing with Sanofi.
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