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Business

Regulus cuts jobs after oligonucleotide safety setback

by Michael McCoy
July 13, 2018 | A version of this story appeared in Volume 96, Issue 29

 

Regulus Therapeutics, a biotech firm developing oligonucleotide drugs that target microRNAs, will cut 60% of its workforce, or about 35 jobs. The decision follows the observation of acute mouse toxicity in a Phase I study of RGLS4326, a treatment for autosomal dominant polycystic kidney disease. The firm also halted recruitment for a study of a microRNA drug it is developing with Sanofi.

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