ADVERTISEMENT
2 /3 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Finance

$50 million more for CARB-X will help biotech companies fight antibiotic resistance

Funds from the Gates Foundation and U.K. government will help address antimicrobial resistance in low- and middle-income countries

by Ryan Cross
May 25, 2018 | APPEARED IN VOLUME 96, ISSUE 22

09622-buscon4-carbx.jpg
Credit: Centers for Disease Control & Prevention
An illustration of carbapenem-resistant Enterobacteriaceae, a bacterium considered a top threat by WHO and CDC.

Since its launch less than two years ago, the public-private partnership CARB-X has provided $85 million to three dozen biotech companies working on new therapies and diagnostics to fight antibiotic resistance.

Now CARB-X, which stands for Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator, has two new funders: The Bill & Melinda Gates Foundation will give up to $25 million, and the U.K. government’s Global Antimicrobial Resistance Innovation Fund is giving up to $27 million (£20 million). With its total funding now over $500 million, CARB-X is quickly becoming a major backer for start-ups developing diagnostic, preventative, and therapeutic products for antibiotic-resistant bacteria.

Kevin Outterson, executive director of CARB-X, says the new funds will be used mostly for “vaccines, prevention, monoclonal antibodies, microbiome, and other nontraditional alternatives to antibiotics, with a particular focus on health needs in low- and middle-income countries.”

The Gates Foundation, well known for funding work to curb malaria, tuberculosis, and diarrheal diseases, is particularly interested in prevention.

Although small-molecule drug development isn’t mentioned as a priority for CARB-X’s newest funding, the organization already backs several small-molecule projects spanning nine new classes of antibiotics. Many of those target Gram-negative bacteria, whose anatomical features make them particularly tough to kill.

CARB-X currently funds 33 projects, which together could receive more than $100 million in additional funds for meeting project milestones.

X

Article:

This article has been sent to the following recipient:

Leave A Comment

*Required to comment