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Investment
BeiGene to codevelop BioAtla’s CTLA4 antibody
by Ryan Cross
April 12, 2019
| A version of this story appeared in
Volume 97, Issue 15
The Chinese cancer drug company BeiGene is partnering with San Diego–based BioAtla to develop a less-toxic version of the CTLA4 antibodies used in cancer immunotherapy. The adoption of CTLA4 antibodies, a kind of checkpoint inhibitor, has been impeded due to their toxicity outside tumors, especially compared with the PD-1 checkpoint inhibitor class. BioAtla has a version that it says is activated only in the tumor microenvironment. BeiGene will pay BioAtla $20 million up front and up to $249 million more in future payments.
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