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Pfizer has agreed to buy Arixa Pharmaceuticals, a California-based company developing oral antibiotics for drug-resistant infections. Pfizer will advance Arixa’s lead compound, ARX-1796, through clinical trials. ARX-1796 is a prodrug of the injection-only antibiotic avibactam. Arixa’s formulation makes avibactam an oral drug. Phase 1 trials show that when take orally 60–80% of ARX-1796 is absorbed into the bloodstream, while only 7% of avibactam is absorbed when taken orally.
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