Allonnia, a spin-off of the synthetic biology firm Ginkgo Bioworks, has launched with $40 million in investor backing to develop microbes capable of breaking tough chemical bonds to battle pollution and treat waste. This is Ginkgo’s third spin-off, after agriculture microbe firm Joyn Bio and ingredient-focused Motif FoodWorks.
Microbes are already used in wastewater treatment to break down organic pollutants. But some organisms can degrade man-made chemicals, including stubborn pollutants like per- and polyfluoralkyl substances (PFAS), says Dayal Saran, Allonnia’s head of R&D.
CEO Nicole Richards says the start-up also plans to develop microbes that bind metals and other valuable materials in waste streams.
Richards, who previously led growth and strategy for DuPont’s water solutions business, acknowledges that PFAS are the toughest challenge on the to-do list. Water treatment facilities can use activated carbon, ion-exchange resins, or reverse osmosis to trap PFAS, but they do not destroy the chemicals. “We think synthetic biology is a more relevant and potentially more complete solution,” Richards says.
PFAS owe their persistence to strong carbon-fluorine bonds. Organisms that can break those bonds are most likely rare, says Peter Jaffé, a professor of civil and environmental engineering at Princeton University. He discovered the ability in a strain of iron-reducing anaerobic bacteria, but the breakdown was slow and incomplete. Scientists are just beginning to characterize the responsible enzymes, Jaffé says.
Another organism that breaks C–F bonds is an aerobic fungi that evolved to digest tough plant lignin, Saran says, and Allonnia’s goal is to turn up the activity. “What we want to do is what takes nature thousands of years.”