ADVERTISEMENT
2 /3 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Metal-Organic Frameworks

MOFs make dialysis more efficient

Study shows porous frameworks can selectively remove blood toxins not thoroughly stripped away by dialysis treatments

by Mitch Jacoby
February 17, 2019 | APPEARED IN VOLUME 97, ISSUE 7

 

09707-scicon10-mofcxd.jpg
Credit: J. Am. Chem. Soc.
MOF NU-1000 features two types of pores that trap p-cresyl sulfate (highlighted in blue). C = black, O = red, Zr = green, S = yellow.

People with faulty kidney function often require dialysis to rid their blood of harmful compounds. Conventional treatments are not perfect. They do a poor job removing a number of toxic compounds, such as p-cresyl sulfate and indoxyl sulfate. These molecules are stripped away by healthy kidneys, but in patients undergoing dialysis they may bind to human serum albumin and remain in the blood. Activated carbon and other adsorbents can trap them, but these materials are not selective—they also capture pharmaceuticals and other molecules that are better left in the body. This lack of selectivity led a Northwestern University team headed by Satoshi Kato and Omar K. Farha to wonder whether metal-organic framework compounds (MOFs), which are highly selective porous crystalline materials, could help trap the toxins. Early results look promising. The researchers chose a series of MOFs on the basis of expected interactions between their binding sites and the toxic compounds’ functional groups and evaluated their trapping efficiency. The top performer, NU-1000, a zirconium-based MOF with pyrene linkers, removed 94% of p-cresyl sulfate from aqueous solutions that simulate the blood of patients with chronic kidney disease (J. Am. Chem. Soc. 2019, DOI: 10.1021/jacs.8b12525). Analyses show that the MOF’s high uptake is due to highly hydrophobic adsorption sites sandwiched between two pyrene linkers and to the presence of Zr6 units, which bind guest molecules’ polar functional groups.

X

Article:

This article has been sent to the following recipient:

Comments
Dr . Swapan Kumar Saha : Is it has already be a membrane to mimic podocyte-endothelial-single-layer of bowman capsule of kidney 's each different filtering unit , the corpuscle . Possibly shunt of blood to get of the body , although very painful , till if this new framed membrane of ultra-filtration get if to get away to like a living system (February 21, 2019 5:27 AM)
The present dialysis membrane is a active carbon , and if this new found membrane is making better than above and mimic the kidney 's corpuscle glomerurous 'ultra filtration , a sandwich of Podocytes 's layer and blood-vessel's afferent arterial end of one-layer , that endothelial . So pore in between differentiated of a space of nano scale , but with fluid of blood to be filtered out -and -in . So podocyte , the ameboid -pseudo-pod , pods in all layer of series itself with insinuating all at in one time into the series of all living endothelial cell-pores . Is something pore of act ....mimetic ...

Leave A Comment

*Required to comment