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Antibiotics

A Helmholtz Centreawarded up to $15 million for small-molecule antibiotics

by Ryan Cross
December 5, 2020 | A version of this story appeared in Volume 98, Issue 47
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Carb-X, a public-private partnership, will award the Helmholtz Center for Infection Research up to $15 million to develop two small-molecule antibiotics. One compound is an inhibitor of α-hemolysin, a toxin employed by Staphylococcus aureus that damages lung tissue and immune cells. The second is an inhibitor of elastase B, a metalloenzyme used by Pseudomonas aeruginosa during infections. Both approaches rely on blunting damage from infections rather than killing the bacteria directly, which could help stall antibiotic resistance.

Chemical & Engineering News
ISSN 0009-2347
Copyright © 2024 American Chemical Society

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