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Drug Delivery

Novo, Dicerna to develop liver disease drugs

by Lisa M. Jarvis
November 23, 2019 | APPEARED IN VOLUME 97, ISSUE 46

 

Novo Nordisk will pay Dicerna Pharmaceuticals $225 million, which includes up-front fees and an equity investment, as part of a broad collaboration to develop RNAi-based therapies targeting liver-related diseases. Dicerna’s technology platform hinges on using a substrate for an enzyme called Dicer to deliver a drug into cells, where it can turn off a specific gene. The companies will work on more than 30 liver cell targets, including ones implicated in nonalcoholic steatohepatitis, type 2 diabetes, and obesity.

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