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Drug Development

Amgen to acquire Rodeo Therapeutics

by Ryan Cross
April 3, 2021 | A version of this story appeared in Volume 99, Issue 12
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Amgen will acquire Rodeo Therapeutics for $55 million plus milestone payments worth up to $666 million. Rodeo’s lead compound is a small-molecule inhibitor of the prostaglandin-degrading enzyme 15-prostaglandin dehydrogenase (15-PGDH). Amgen says the compound could treat several diseases, including inflammatory conditions. Researchers have found that inhibiting 15-PGDH in animals promotes tissue repair, protects against colitis and idiopathic pulmonary fibrosis, and helps rebuild blood stem cell populations after bone marrow transplantation.

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