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Drug Development

Esker Therapeutics launches for TYK2 inhibition

by Ryan Cross
May 7, 2021 | A version of this story appeared in Volume 99, Issue 17
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Esker Therapeutics has launched with $70 million in series A financing from the investment firm Foresite Capital to develop drugs for autoimmune diseases. The San Francisco–based start-up’s lead program is an inhibitor of a tyrosine kinase called TYK2. It’s in a Phase 1 clinical trial as a treatment for psoriasis. Esker says the compound is more selective for TYK2 than it is for JAK1, a similar kinase. Bristol Myers Squibb and Pfizer also have TYK2 inhibitor programs.

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