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Drug Development

Lilly partners on Rigel’s RIPK1 inhibitors

by Ryan Cross
February 28, 2021 | A version of this story appeared in Volume 99, Issue 7
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Eli Lilly and Company will collaborate with Rigel Pharmaceuticals to develop a small-molecule inhibitor of RIPK1, a kinase involved in cell death and inflammation. Lilly will pay Rigel $125 million up front and up to $835 in milestone payments. The pair will test the molecule in Phase 2 trials of autoimmune and inflammatory diseases this year. RIPK1 is also linked to neurodegenerative diseases including Alzheimer’s and amyotrophic lateral sclerosis, and Lilly plans tests of a brain-penetrating RIPK1 inhibitor to treat central nervous system diseases.

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