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Drug Development

Novel antifungal wins FDA approval

by Megha Satyanarayana
June 11, 2021 | A version of this story appeared in Volume 99, Issue 22
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Most Popular in Pharmaceuticals

The structure of ibrexafungerp.

The US Food and Drug Administration has approved Brexafemme, an oral antifungal for vaginal yeast infections developed by the biotech firm Scynexis. The drug’s active compound, ibrexafungerp, is a glucan synthase inhibitor that is in a new class of drugs called triterpenoids. The compound, which Scynexis calls the first approved novel antifungal in more than 20 years, is effective against Candida species, including some drug-resistant strains.

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