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Pfizer will pay $650 million up front and up to $4.2 billion in milestone payments to Myovant Sciences to jointly develop relugolix, an oral gonadotropin-releasing hormone receptor antagonist. The drug, which reduces testicular testosterone, was recently approved in the US for treating advanced prostate cancer. Relugolix also reduces ovarian estradiol. A tablet containing relugolix and a small amount of estradiol and norethindrone acetate is under regulatory review for treating uterine fibroids and is in clinical studies for treating endometriosis.
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