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Drug Discovery
Could an NLRP3 inhibitor be the one drug to conquer common diseases?
A large number of diseases have been linked to the NLRP3 inflammasome. The race is on to develop drugs that disrupt it
by Ryan Cross
February 17, 2020
| A version of this story appeared in
Volume 98, Issue 7
Credit: C&EN/Protein Data Bank, PDB ID 3JBL (NLRP3); Protein Data Bank, PDB ID 6CB8 (gasdermin-D) | Cryogenic electron microscopy models of inflammasome rings (center, ring with hooks) and gasdermin pores (bottom right)
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