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Drug Discovery

Lilly taps ProQR for RNA editing

by Ryan Cross
September 18, 2021 | A version of this story appeared in Volume 99, Issue 34
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Eli Lilly and Company is partnering with ProQR Therapeutics to develop up to five RNA-editing therapies for genetic diseases of the liver and nervous system. ProQR is one of several firms designing oligonucleotides that recruit a human enzyme called ADAR to make single-nucleotide changes in RNA. In August, Roche partnered with Shape Therapeutics to develop similar RNA-editing systems. ProQR will get $50 million up front and milestone payments of up to $1.25 billion.

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