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Drug Discovery

Orum raises $84 million for protein-degrader antibodies

by Ryan Cross
June 26, 2021 | A version of this story appeared in Volume 99, Issue 24
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Orum Therapeutics has raised $84 million in series B financing to develop antibody-drug conjugates that deliver small-molecule protein degraders to cancer cells. When the antibodies bind a target on the surface of a cancer cell, they are engulfed and digested, then release a degrader. The degrader then binds to an intracellular protein and tags it for degradation. The start-up, based in Cambridge, Massachusetts, and Daejeon, South Korea, will use the money to advance programs for undisclosed targets in solid tumors and blood cancers.

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