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Drug Discovery

Vertex to make degrader-antibody conjugates

by Rowan Walrath
July 22, 2024 | A version of this story appeared in Volume 102, Issue 22
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Vertex Pharmaceuticals is slated to develop degrader-antibody conjugates using targeted protein degradation technology from the South Korean biotech firm Orum Therapeutics. Vertex is paying Orum $15 million up front and a potential $310 million in milestone payments to use Orum’s platform. The Boston pharmaceutical firm intends to pair the degrader-antibody conjugates with gene editing, building on its success with the CRISPR medicine Casgevy.

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