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Drug Discovery

Vertex taps Mammoth Bio for CRISPR work

by Ryan Cross
October 30, 2021 | A version of this story appeared in Volume 99, Issue 40
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Vertex Pharmaceuticals is expanding its investment in CRISPR through a partnership with Mammoth Biosciences, a start-up cofounded by CRISPR gene-editing inventor Jennifer Doudna. Vertex will pay Mammoth $41 million up front and up to $650 million in future payments to use the start-up’s ultracompact Cas enzymes, whose small size could make delivery into the body easier. The firms will develop therapies for two undisclosed genetic diseases. Vertex is already developing a gene-editing therapy for sickle cell disease with the firm CRISPR Therapeutics.

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