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Gene Therapy

Takeda, Carmine join to treat rare diseases

by Michael McCoy
July 4, 2020 | A version of this story appeared in Volume 98, Issue 26
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Takeda Pharmaceutical will pay Carmine Therapeutics an undisclosed sum and up to $900 million in milestone payments as part of a deal to develop nonviral gene therapies for two rare diseases. Carmine was founded last year in Cambridge, Massachusetts, to pioneer a new class of gene therapies based on red blood cell extracellular vesicles (RBCEVs). Compared to adeno-associated virus-based gene therapy, RBCEV-based gene therapy has the potential for larger payloads and repeat dosing, Carmine says.

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