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Bristol Myers Squibb and Insitro have struck a 5-year collaboration to discover and develop therapies for two neurodegenerative diseases: amyotrophic lateral sclerosis and frontotemporal dementia. Insitro, a San Francisco–based start-up founded in 2018, will use machine learning and induced pluripotent stem cell models to identify targets and drug candidates. BMS will pay Insitro $50 million up front and possibly $2 billion more in future milestones.
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