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Oncology

Boehringer Ingelheim to acquire ADC firm NBE-Therapeutics

by Michael McCoy
December 17, 2020 | A version of this story appeared in Volume 98, Issue 48
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Boehringer Ingelheim will enter the antibody-drug conjugate (ADC) field by acquiring the Swiss firm NBE-Therapeutics for about $1.4 billion. NBE conjugates antibodies to anthracycline-based toxins, which it says are much more potent than the toxins in approved ADCs such as Adcetris and Kadcyla. NBE says it uses enzymatic conjugation to keep toxins tethered to antibodies until they are taken up by tumor cells. Its lead candidate, NBE-002, is in Phase 1 trials.

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