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Oncology

Bristol-Myers Squibb taps Repare’s CRISPR screens for cancer drug discovery

by Ryan Cross
May 29, 2020 | A version of this story appeared in Volume 98, Issue 21
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Bristol-Myers Squibb will pay Repare Therapeutics $65 million and invest $15 million in the start-up as part of a cancer drug–discovery deal. Some common mutations in cancer cells impair their ability to fix damaged DNA, forcing the cells to rely on alternative DNA repair mechanisms as a crutch. Repare uses CRISPR-Cas9 gene-editing screens to knock out genes, pinpoint the proteins responsible for the crutch, and design small-molecule drugs to target them. The strategy is called synthetic lethality. Repare could earn up to $3 billion in milestone payments from BMS.

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