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Oncology

GSK will acquire cancer drug firm Tesaro

by Ryan Cross
December 14, 2018 | A version of this story appeared in Volume 96, Issue 49
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The structure of niraparib.

GlaxoSmithKline will purchase Tesaro, which sells a PARP inhibitor cancer drug, for $5.1 billion. Niraparib, sold under the name Zejula, inhibits an enzyme involved in DNA repair called poly(ADP-ribose) polymerase, or PARP. Blocking PARP-mediated DNA repair in tumors that already have a gene mutation can deal the tumors a fatal blow. In the first three quarters of 2018, Tesaro posted only $166 million in niraparib sales, but GSK is counting on revenues to increase in the future.

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