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Oncology

Genentech strikes cancer drug deal with Bicycle

by Ryan Cross
March 7, 2020 | APPEARED IN VOLUME 98, ISSUE 9

 

09809-buscon18-bicycle.jpg
Credit: Bicycle/C&EN
Bicycle's bicyclic peptides can be linked to anticancer toxins.

Genentech is teaming up with Bicycle Therapeutics to develop cancer immunotherapies. Bicycle uses chemical scaffolds to turn linear peptides into two pretzel-like loops. The firm says these so-called bicyclic peptides can be used as drugs alone or to deliver toxic payloads to cancer cells. Bicycle has several cancer drug programs of its own. Genentech will pay Bicycle $30 million up front—and up to $1.7 billion in milestone payments—to develop bicyclic peptides against several new targets.

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