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Oncology
New covalent drug collaboration
by Shi En Kim
April 1, 2023
| A version of this story appeared in
Volume 101, Issue 11
Covant has entered a collaboration with Boehringer Ingelheim to develop small-molecule covalent drugs for immuno-oncology. The companies aim to inhibit an RNA-specific adenosine deaminase enzyme to improve the immune system’s response to tumors by turning “cold” tumors into “hot” tumors. The developers plan for their inhibitor to be combined with other immunotherapies. Boehringer Ingelheim will pay Covant $10 million up front for the discovery of covalent candidates and $471 million in potential milestones, plus royalties.
Chemical & Engineering News
ISSN 0009-2347
Copyright © 2024 American Chemical Society
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