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Oncology

Notorious KRAS: Taking down cancer researchers’ biggest foe

After decades of failures, the first wave of KRAS G12C inhibitors has reached the clinic. Can the feat be repeated with other RAS proteins?

by Lisa M. Jarvis
September 23, 2019 | A version of this story appeared in Volume 97, Issue 37
A crystal structure of KRAS G12C with the chemical structure of Amgen's AMG 510 tucked into a pocket.

Credit: Will Ludwig/C&EN/Amgen | Amgen's AMG 510, shown here bound to its protein target, was the first KRAS G12C inhibitor to be tested in humans.

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