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September 23, 2019 Cover

Volume 97, Issue 37

After decades of failures, the first wave of KRAS G12C inhibitors has reached the clinic. Can the feat be repeated with other RAS proteins?

Cover image:After decades of failures, the first wave of KRAS G12C inhibitors has reached the clinic. Can the feat be repeated with other RAS proteins?

Credit: Will Ludwig/ C&EN/ Amgen

Full Article

Notorious KRAS: Taking down cancer researchers’ biggest foe

After decades of failures, the first wave of KRAS G12C inhibitors has reached the clinic. Can the feat be repeated with other RAS proteins?

  • At chemical maker Nouryon, the transformation begins

    Former AkzoNobel business eyes billion-dollar acquisitions, expansions, and divestments

  • Meet the group providing science and technology information to the US Congress

    The Government Accountability Office aims to improve quality, timeliness of reports on emerging disruptive technologies

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Cancer

Some anticancer molecules are off target

Experiments in cell lines suggest that the molecules kill cancer cells through targets they weren’t designed to hit

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