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September 23, 2019 Cover
Volume 97, Issue 37
After decades of failures, the first wave of KRAS G12C inhibitors has reached the clinic. Can the feat be repeated with other RAS proteins?
Cover image:After decades of failures, the first wave of KRAS G12C inhibitors has reached the clinic. Can the feat be repeated with other RAS proteins?
Credit: Will Ludwig/ C&EN/ Amgen
Notorious KRAS: Taking down cancer researchers’ biggest foe
After decades of failures, the first wave of KRAS G12C inhibitors has reached the clinic. Can the feat be repeated with other RAS proteins?
Chemists grapple with lack of diversity displayed in ‘dude walls’ of honor
Academics share tales of rethinking the all-male portrait galleries in their departments
Can nuclear power help save us from climate change?
The technology’s slide must be reversed, the International Energy Agency says, but significant barriers exist
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At chemical maker Nouryon, the transformation begins
Former AkzoNobel business eyes billion-dollar acquisitions, expansions, and divestments
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Meet the group providing science and technology information to the US Congress
The Government Accountability Office aims to improve quality, timeliness of reports on emerging disruptive technologies
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Science Concentrates
- Microfluidic device brews human embryo–like structures
- Hospital bacteria can colonize the guts of babies born by C-section
- Calcium carbide powers water-leaping robot
- Following in a fungus's footsteps, chemists synthesize preuisolactone A in only 3 steps
- Evolved enzyme improves route to drug candidate
Some anticancer molecules are off target
Experiments in cell lines suggest that the molecules kill cancer cells through targets they weren’t designed to hit
Business & Policy Concentrates
- Petrochemical prices spike after Saudi bombings
- Ginkgo raises $290 million, pairs with start-up accelerators for organism engineering
- US EPA to rework controversial science information plan
- US EPA proposes to waive pesticide toxicity test on birds
- Biotech start-up Divide & Conquer launches to disrupt cancer cell communication
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