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Oncology

Pfizer invests in and partners with Oric

by Shi En Kim
December 29, 2022 | A version of this story appeared in Volume 101, Issue 1
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Pfizer will collaborate with Oric Pharmaceuticals on a Phase 2 study of a small-​molecule multiple myeloma treatment. The drug candidate, ORIC-533, is an inhibitor of the enzyme CD73 and will be deployed in the clinic in combination with a Pfizer antibody. CD73 controls the rate at which extracellular adenosine is produced, and its overexpression is associated with poor prognosis in several cancers, Oric says. Under the deal, Pfizer will make an equity investment in Oric amounting to $25 million.

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