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Small biochemical changes after year in space

Twin astronauts show space travel can induce genetic changes

by Sam Lemonick
April 12, 2019 | APPEARED IN VOLUME 97, ISSUE 15


Credit: NASA/Robert Markowitz
A year in space changed astronaut Scott Kelly's (right) DNA relative to his brother Mark Kelly (left) on Earth, although most changes reversed after Scott's return.

NASA astronaut Scott Kelly spent almost 1 year on the International Space Station (ISS). His twin brother, Mark, spent that year on Earth. Now scientists are delivering their full report on the relative effects of living in space (Science 2019, DOI: 10.1126/science.eaau8650). Researchers found that Scott’s telomeres—molecular caps on chromosomes known to get shorter over an organism’s life span—became longer while he was aboard the ISS, but they quickly returned to preflight lengths on his return. On some chromosomes, they eroded completely. Scott also experienced changes in DNA methylation—which can change a gene’s expression—in immune cells, patterns the researchers say are associated with stress. Interestingly, his twin saw different methylation changes but of greater magnitude. In Scott, they also saw increased chromosome aberrations consistent with radiation exposure. The researchers acknowledge the study’s imperfections. It had a tiny sample size and Mark’s activities and diet were not controlled. And because Earth’s magnetic field shields the ISS from some radiation, Scott’s experience may not translate to deep space missions.



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Dr. Alex Sobko, PhD (April 16, 2019 11:39 PM)
Full length article on this study by reknown American institutions is freely available on Science magazine website. Among the most interesting findings over 25 months space flight are chromosome inversions (that may increase a risk of cancers in the future), elongation and then shortening of some telomers, and changes in DNA methylation of genes involved in oxidative stress and immune response. Luckily for the austranaut, most of the changes detected returned to pre-flight baseline. Anyway, interesting promising study, inspiring to investigate larger groups of austranauts over longer periods of space flights in the future. But, tween study makes it really unique.

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