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Synthesis

Chemistry In Pictures

Chemistry in Pictures: Don’t drink the tetrazine

by Manny I. Fox Morone
July 29, 2024
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A beaker filled to the brim with a fine pink foam made of a tetrazine sits on a countertop at AxisPharm.
Credit: Bharvi Sharma

Bharvi Sharma had a feeling the tetrazine amine compound that she was trying to synthesize would have a strong color, but she didn’t expect this vibrant pink foam. Tetrazines are useful because they can participate in a click chemistry reaction that quickly links together two molecules and produces almost no by-products. The reaction is so clean that it has even been pulled off inside the human body. Sharma, a scientist at AxisPharm in San Diego, was making this tetrazine to link antibodies to drug molecules. Antibody-drug conjugates are a type of targeted drug that uses the antibody portion to find and bind to a diseased cell with the intention of delivering the attached drug to exactly where it needs to go.

Submitted by Bharvi Sharma

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