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Navigating the financing doldrums in 2024

Despite a handful of megarounds, many firms struggled to stay afloat

Shortages created opportunities for counterfeits

Authorized versions and illegal copies of GLP-1 agonists emerged

Pharma’s memorable moments of 2024

The headlines and highlights that the C&EN team found noteworthy this year

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Chemical Regulation

EPA seeks to protect workers from carbon tetrachloride

Final rule allows current uses of the toxic solvent with a new inhalation limit


EPA bans 2 common chlorinated solvents

Trichloroethylene and perchloroethylene phase-out plan includes exemptions for some critical applications

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Biochemistry

Wnt protein hitches a ride on exosomes

Researchers have found a domain on a Wnt protein that allows it to stick to vesicles


Dueling glue degraders take on sickle cell disease

Small molecules hint at a new treatment option for the inherited blood disorder

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Start-ups

Siftr Bio will design new ADC linkers

Spin-out from Ed Tate’s lab focuses on improving conjugate chemistry in the popular anticancer modality