Volume 89 Issue 38 | p. 9 | News of The Week
Issue Date: September 19, 2011

Extreme Photoswitching

Microscopy: Fluorescent proteins that turn on and off many more times than usual improve superresolution methods
Department: Science & Technology
News Channels: Nano SCENE
Keywords: microscopy, imaging, live cell, fluorescence, superresolution

Two new photoswitchable fluorescent proteins that can be repeatedly turned on and off extend the capabilities of superresolution fluorescence microscopy, German researchers report in a pair of papers. The proteins may find use in biological imaging and data storage.

Stefan W. Hell, Stefan Jakobs, and coworkers at the Max Planck Institute for Biophysical Chemistry, in Göttingen, mutated existing fluorescent proteins to generate the new proteins. Starting with a yellow fluorescent protein called . . .

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