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Biological Chemistry

Ancient Rocks Suggest Meteorites Brought Life’s Phosphorus To Earth

Origins of Life: Reactive phosphorus compounds eventually became part of DNA, RNA, cell membranes

by Carmen Drahl
June 7, 2013 | A version of this story appeared in Volume 91, Issue 23

Credit: Courtesy of Matthew Pasek
“I had these rocks for six years,” Pasek says, before he was able to adapt a mass spectrometry technique to analyze their phosphorus content.
Photo shows a 3.5 billion-year old Australian rock. The bottom edge of this Coonterunah carbonate is about 2 cm across.
Credit: Courtesy of Matthew Pasek
“I had these rocks for six years,” Pasek says, before he was able to adapt a mass spectrometry technique to analyze their phosphorus content.

Ancient rocks from Australia have long been known to contain chemical clues about early Earth. A new look at these 3.5 billion-year-old rocks now provides a possible explanation for how the element phosphorus became a crucial part of life’s biochemistry.

Today, in its +5 oxidation state as phosphate, phosphorus powers adenosine triphosphate to energize life processes and helps form the structural backbone of DNA and RNA. However, “the origins-of-life community has struggled with the problem of how phosphate first entered into life,” says Nicholas V. Hud of Georgia Tech, who was not involved with the new study. Most phosphate on Earth is inorganic. It is insoluble in water and too inert to easily incorporate into biomolecules.

The new work, from Matthew A. Pasek of the University of South Florida and colleagues, suggests that the planet’s phosphorus makeup was once very different. The group found phosphite, with phosphorus in its +3 oxidation state, in ancient rocks. Phosphite dissolves in water and is reactive enough to be a plausible phosphorus source for proto-biomolecules (Proc. Natl. Acad. Sci. USA 2013, DOI: 10.1073/pnas.1303904110). What’s more, other scientists have found traces of early life—the outlines of primitive cells—in rocks from this region of Australia.

The find provides geochemical evidence for Pasek’s 2008 proposal that meteorites delivered reactive phosphorus to Earth in the form of a mineral called schreibersite. When dissolved in water, schreibersite releases phosphite and other reactive phosphorus species.

To test the theory that phosphorus might have made its way from schreibersite into biomolecules, Pasek’s team took a commercial reagent that mimics schreibersite and combined it with glycerol, a three-carbon alcohol also common in meteorites. After heating the material to 65 °C in water, they obtained glycerol phosphate, a cell membrane building block.

That result is intriguing, says Matthew W. Powner of University College London, who studies primeval RNA synthesis. But the reaction is quite complex, he adds, which makes it hard to verify that phosphite is responsible for adding the phosphorus to glycerol.

Pasek agrees. He says the reaction only demonstrates that schreibersite allows phosphate transfer to happen. His team plans to study the reaction mechanism and examine its scope.



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