Volume 92 Issue 18 | p. 9 | News of The Week
Issue Date: May 5, 2014

Antibiotic May Sidestep Resistance

Drug Discovery: Bacteria may find agent’s mechanism hard to circumvent
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: antibiotic, rifamycin, GE23077, resistance

Researchers finally know exactly how the promising antibiotic GE23077 (GE) inhibits an essential bacterial enzyme. They predict that GE’s ability to hit this enzyme in its active site could make it difficult for bacteria to develop resistance to the agent. The study also shows how GE might be conjugated with another antibiotic to make a combination drug the scientists believe might be unusually resistance-proof.

Some bacterial infections are difficult or impossible to treat effectively because . . .

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