Issue Date: November 3, 2014
Chemical Ligation Builds Synthetic Lipid Membranes
Native chemical ligation isn’t just for building big peptides anymore.The reaction, which forms amide bonds in water without enzymes, has also been used to construct nucleic acids. Now, chemists have shown that the ligation can even generate phospholipids, which then spontaneously form vesicles about the size of a skin cell (Angew. Chem. Int. Ed. 2014, DOI: 10.1002/anie.201408538). Enzymes in nature make phospholipids with thioester precursors, and . . .
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