ADVERTISEMENT
2 /3 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Biological Chemistry

Fidgety-Enzyme Inhibitor Speeds Wound Healing

Molecular Medicine: Nanoparticle siRNA inhibits enzyme that slows advance of healing skin cells toward wounds

by Stu Borman
April 13, 2015 | APPEARED IN VOLUME 93, ISSUE 15

Researchers have designed a nanoparticle-based small interfering RNA (siRNA) that doubles the speed of wound healing in mice (J. Invest. Dermatol. 2015, DOI: 10.1038/jid.2015.94). David J. Sharp of Albert Einstein College of Medicine, in the Bronx, N.Y., who led the team behind the development, says he believes that if such an agent is approved after further testing, it could aid healing of cuts and burns, surgical incisions, and skin ulcers. Sharp and coworkers previously found that an enzyme called fidgetin-like 2 (FL2) causes skin cells to move more slowly toward wounds than they would be capable of doing if the enzyme weren’t holding things up. They therefore identified an siRNA that binds to FL2 mRNA, inhibiting translation of the expressed enzyme. The siRNA is degraded easily and doesn’t enter cells efficiently, so the researchers developed a nanoparticle delivery system that makes it more effective. The team found no evidence of toxicity in mice and plans to test the therapy on pigs. The technology has been licensed by MicroCures, in Santa Cruz, Calif., a company Sharp founded.

X

Article:

This article has been sent to the following recipient:

Leave A Comment

*Required to comment