The first nickel-catalyzed Suzuki-Miyaura coupling using an amide derivative as a cross-coupling partner has been reported by chemists at UCLA (Nat. Chem. 2015, DOI: 10.1038/nchem.2388). Suzuki-Miyaura couplings are wildly popular for forging C–C bonds: The prototype reaction uses a palladium catalyst to link an organoboron reagent with an electrophile, such as an organohalide. In recent years, chemists have investigated nickel catalysts for these types of reactions because the metal is more abundant and less expensive. Neil K. Garg, Nicholas A. Weires, and Emma L. Baker found they could use a nickel catalyst to activate an amide’s C–N bond so that it undergoes cross-coupling with a boronic ester to produce an acyl C–C bond. Organic chemists have historically considered amides to be inert substrates, the authors note, but this work adds to a growing body of evidence that certain conditions can make them useful in organic synthesis. The new reaction tolerates a broad range of functional groups, including ketones and amines. The UCLA chemists used the transformation to create an antiproliferative agent (shown) on a gram scale.