Cooking up the ultimate sweetener | Chemical & Engineering News
Volume 94 Issue 39 | p. 12 | Latest News
Web Date: September 30, 2016

Cooking up the ultimate sweetener

Manus Biosynthesis has developed a scalable fermentation process to make rebaudioside M, a highly sought zero-calorie sugar substitute
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: food ingredients, stevia, rebaudioside, artificial sweetener, sugar

Manus Biosynthesis has announced the development of an engineered bacterium and scalable fermentation process to make commercial quantities of the sought-after zero-calorie natural sweetener rebaudioside M for the first time. Known as Reb M, the molecule is one of a set of steviol glycosides produced by the stevia plant that are popular as noncaloric sweeteners to replace sugar and high-fructose corn syrup in soft drinks and foods. Most commercial stevia products are based on stevioside and rebaudioside A, which are the most abundant steviol glycosides. However, similar to some artificial sweeteners, these compounds have subtle unfavorable bitter and metallic off-tastes that become more pronounced at higher concentrations. Among the steviol glycosides, Reb M has been flagged as having the best overall taste profile and favorable properties for beverage and food processing, according to Manus Biosynthesis founder and chief executive Ajikumar Parayil. Yet its low levels in the stevia plant, at less than 0.01% of leaf weight, has made it difficult to source economically. Building on core technology developed by MIT’s Gregory Stephanopoulos and coworkers, Manus Biosynthesis has succeeded in demonstrating production of bulk amounts of Reb M in better than 95% purity and published results in a recent patent application (WO2016073740).

Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society
Isabel (October 2, 2016 1:00 PM)
this is so weird, but crazy!

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