Volume 94 Issue 46 | p. 11 | Concentrates
Issue Date: November 21, 2016

Cannabinoid receptor revealed

Two research teams separately publish the first crystal structures of the CB1 receptor
Department: Science & Technology
Keywords: neuroscience, cannabinoid, CB1, cannabinoid receptor

Two research groups have independently elucidated the first crystal structures of the cannabinoid receptor CB1, a cell-membrane protein involved in a host of appetite, pain-sensation, memory, and other physiological processes. The protein’s floppy movements between active and inactive states make it difficult to study, so Alexandros Makriyannis of Northeastern University and colleagues designed a strong inhibitor to bind and help immobilize CB1 to get a better glimpse of its structure (Cell . . .

To view the rest of this content, please log in with your ACS ID.

Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society