Issue Date: March 5, 2018
Flipping from E- to Z-alkenes
In their search for new medicines, chemists often choose the trusty Suzuki-Miyaura reaction to construct essential carbon-carbon bonds. This reliable reaction connects alkyl halides with various classes of organoborane compounds, including alkenyl organoboranes, which can be further classified by alkene configuration, either cis (Z) or trans (E). E-alkenylboron compounds are faster and simpler to make than their thermodynamically unfavored twin, the Z-configured compounds, and thus have received more attention as precursors for the Suzuki-Miyaura reaction. . . .
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