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In June 2018, Celgene announced a $60 million partnership with Skyhawk Therapeutics to develop small-molecule drugs that alter RNA splicing. The pharma firm is striking a second deal with Skyhawk, worth $80 million up front, to develop small molecules for traditionally undruggable targets in autoimmune diseases, cancer, and immuno-oncology. The first partnership, which is ongoing, focuses on neurological diseases such as amyotrophic lateral sclerosis and Huntington’s disease. Skyhawk is one of C&EN’s 10 Start-Ups to Watch this year.
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