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Most Popular in Biological Chemistry
Sanofi will pay Nurix Therapeutics $55 million up front and up to $2.5 billion in future milestones to collaborate on targeted protein degradation therapies. Nurix will use DNA-encoded libraries and E3 ligases to create small molecules designed to induce degradation—rather than mere inhibition—of three specified protein drug targets. Nurix signed a similar deal with Gilead Sciences in June that was focused on cancer and other diseases. Biotech firms like Arvinas and Kymera Therapeutics are also developing protein degraders
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