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Drug Development

BMS partners with A-Alpha Bio on molecular glues

by Gina Vitale
August 28, 2022 | A version of this story appeared in Volume 100, Issue 30
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Bristol Myers Squibb will team up with the synthetic biology and machine learning firm A-Alpha Bio to find targets for molecular glues, which are small molecules often used to join badly behaving proteins to enzymes that mark them for destruction. A-Alpha will identify enzymes and protein targets that could be ripe for gluing; BMS can use the pairings to develop molecular glues. A-Alpha will receive an up-front payment of an undisclosed amount and be eligible for milestones. BMS already has several molecular glue drugs approved or in clinical trials.

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