Copyright © 2004 American Chemical Society
 

February 16, 2004 Issue

Volume 82, Issue 7
8207cover1_open
February 16, 2004 Issue, Vol. 82 | Iss. 7
Major drug firms have marshaled new technologies and business practices in discovery and development--have they jump-started the machine?
By Rick Mullin
(p.23)
Features
Science & Technology
Thin tubes between cells transport organelles but block small molecules 
Science & Technology
Evidence continues to accumulate that mold can cause illness, but the degree of hazard is unclear (pp. 57-58)
Back Issues
 

Cover Story: PRIMING THE PIPELINE

DRUGMAKERS FACE AN ANGRY PUBLIC
On top of pipeline woes, U.S. pharmaceutical producers are confronted with external pressures
(pp. 38-42)
 

News of the Week

INTERCELLULAR TELEPHONE WIRES

Thin tubes between cells transport organelles but block small molecules
(p.9)

MERCK ADVANCES LICENSING AGENDA

Deal with Lundbeck lands a late-stage compound for sleep disorders
(p.10)

VACCINES' LINK TO AUTISM UNCLEAR

Researchers present conflicting evidence over role of preservative
(p.10)

REPAIR ENZYME FLIPS AND SNIPS

Structure fills out picture of how cells carry out error-free repair of DNA
(p.11)

CHEMICAL FIRMS IN FUEL FIRSTS

Companies say technologies will lead to less dependence on fossil fuels
(p.12)

HOW ARCTIC FISH AVOID FREEZING

Key structure of antifreeze glycoproteins inhibits ice formation
(p.13)
 

Departments

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Science & Technology

NEW SOFTWARE AND WEBSITES FOR THE CHEMICAL ENTERPRISE
(p.66)
Dampness brings mold in; volatile compounds, ergosterol, and a glucan reveal its presence
(pp. 60-61)
Evidence continues to accumulate that mold can cause illness, but the degree of hazard is unclear
(pp. 57-58)
On top of pipeline woes, U.S. pharmaceutical producers are confronted with external pressures
(pp. 38-42)
Guru of catalytic asymmetric oxidation regaled his audience with adventures in click chemistry
(pp. 63-65)

Newscripts

(p.104)

Editor's Page

Letters

Letters(p.4)