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February 19, 2018 Cover

Volume 96, Issue 8

The new modality promises to open up the human proteome to drug developers, but first they will need to work out the rules

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Volume 96 | Issue 8

All Issues

Targeted protein degraders are redefining how small molecules look and act

The new modality promises to open up the human proteome to drug developers, but first they will need to work out the rules

  • Periodic graphics: The chemistry of air fresheners

    Chemical educator and Compound Interest blogger Andy Brunning sniffs out an answer to the question of whether air fresheners actually ‘kill’ bad odors

  • Vaccines against addictive drugs push forward despite past failures

    Vaccines could help prevent relapses but have yet to be effective in clinical trials

  • India’s science and technology funding raised marginally

    Proposed 2018 budget prioritized information technology and health care over basic science

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Biological Chemistry

Genetic screen of soil microbes uncovers novel antibiotics

Method could help researchers discover new natural products from hard-to-culture microorganisms

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