Covalent drugs go from fringe field to fashionable endeavor
Designing molecules that make bonds with their biological targets is in vogue
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Copyright © 2024 American Chemical Society
November 9, 2020 Cover
Volume 98, Issue 43
Designing molecules that make bonds with their biological targets is in vogue
Cover image:The drug ibrutinib makes a covalent bond to Bruton’s tyrosine kinase, an important cancer target.
Credit: RCSB PDB/Yang H. Ku/C&EN
Volume 98 |
Issue 43
Drug Discovery
1,4-Dioxane: Another forever chemical plagues drinking-water utilities
Highly miscible in water, the likely carcinogen is challenging to remove
Racial and ethnic diversity of US chemistry faculty has changed little since 2011
The Open Chemistry Collaborative in Diversity Equity hopes data will help departments improve faculty’s diversity, inclusion, and equity
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We’re all science communicators. Here’s how to do it better
Jen Heemstra on how to help those around you separate facts from myths
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Spider silk proteins condense into droplets to form silk
Scientists report that a phenomenon called liquid-liquid phase separation causes the silk proteins to solidify
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A new way to get P from pee
An electrochemical method could make phosphorus recycling easier, but it is yet to be proven in the real world at scale
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Science Concentrates
Chemistry awaits US presidential pick
A switch to Biden would change pandemic, environment, and immigration policies; Congress has a bigger role in other areas
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