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November 9, 2020 Cover

Volume 98, Issue 43

Designing molecules that make bonds with their biological targets is in vogue

Cover image:The drug ibrutinib makes a covalent bond to Bruton’s tyrosine kinase, an important cancer target.

Credit: RCSB PDB/Yang H. Ku/C&EN

Full Article
Volume 98 | Issue 43

All Issues

Quote of the Week

“This is definitely a moment of reflection for our nation—and one cannot effectively reflect without knowing the facts.”

Dontarie Stallings, associate director, Open Chemistry Collaborative in Diversity Equity

Drug Discovery

Covalent drugs go from fringe field to fashionable endeavor

Designing molecules that make bonds with their biological targets is in vogue

  • We’re all science communicators. Here’s how to do it better

    Jen Heemstra on how to help those around you separate facts from myths

  • Spider silk proteins condense into droplets to form silk

    Scientists report that a phenomenon called liquid-liquid phase separation causes the silk proteins to solidify

  • A new way to get P from pee

    An electrochemical method could make phosphorus recycling easier, but it is yet to be proven in the real world at scale