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March 11, 2019 Cover
Volume 97, Issue 10
After decades of focus on proteins’ active sites, a new crop of biotech firms is shifting attention to proteins’ hidden regulatory pockets
Cover image:A protein with a series of keyholes on it, surrounded by scientists hands holding a key.
Credit: Chris Gash; Hotspot Therapeutics (protein)
Drug hunters explore allostery’s advantages
After decades of focus on proteins’ active sites, a new crop of biotech firms is shifting attention to proteins’ hidden regulatory pockets
The fight over the longest carbon-carbon bond is redefining what a bond is
Why chemists are pushing C–C bonds to their limits
Fingerprints are more than just patterns; they’re chemical identities
Researchers are developing chemical analyses and advanced DNA techniques to get more evidence out of fingerprints
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How a new epoxy could boot BPA from cans
Scientists went back to the drawing board to create a metal-can lining without bisphenol A’s endocrine effects
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Brazilian chemist Joana D’Arc Félix de Sousa on her path from poverty to PhD and inventor to teacher
Raised by a tanner and a maid, she now advocates for underprivileged youth
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Your guide to the 2019 ACS Spring National Meeting in Orlando
C&EN’s editors pick the speakers and symposia to catch
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Science Concentrates
FDA commissioner Scott Gottlieb to step down
His brief stint as agency chief brought progress in approving generic drugs and advancing new technologies
